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In a meta-analysis of 10 placebo-controlled trials including over 71,000 subjects with or without diabetes at recruitment, treatment with SGLT2 inhibitors reduced the risk of heart failure hospitalization or cardiovascular death by 24% and lowered the risk of poor renal outcomes by 32% (Barbarawi 2021)
When you can tolerate your current dose for two weeks with minimal or no GI side effects, you are ready to increase
Compounded formulations come in different concentrations, and calculating the correct injection volume requires knowing your vial concentration and target dose
Violett B, Horman S, Leclerc J, et al
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