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Medication Options During Maintenance Continuing Semaglutide or Tirzepatide For some adults, continued GLP-1 therapy may be medically appropriate because obesity is a chronic condition
In mammals, cobalamin is a cofactor for only two enzymes, methionine synthase and L-methylmalonyl-coenzyme A mutase (2)
But about half of people with obesity on this class of medications, called glucagon-like peptide agonists or GLP-1s, stop taking it within a year
Injectable GLP-1 medications require weekly or twice-weekly subcutaneous administration, making injection-site tolerability a genuine quality-of-life concern
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