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Safranal, a monoterpene aldehyde responsible for the characteristic smell of saffron, is an antioxidant that contributes to lowering oxidative stress in the neurons, inhibiting the production of pro-inflammatory cytokines and balancing the equilibrium between free radicals and antioxidants activity (Seyedinia et al., 2023)

Notably, although experimental team found that hepatic DCs prevent NK cells activation and attract neutrophils apoptosis during APAP challenge, the aggravation of liver injury by DCs depletion is not correlated with NK cells, neutrophils and various inflammatory mediators [133]

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