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Aseptic necrosis of acinar cells is a key event in AP, and IL-1 is a central effector cytokine involved in sterile injury mediated by the innate immune response, which is typically produced by monocytes and macrophages
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PLoS One 11:e0152074
It is approved for individuals with a body mass index (BMI) of 30 or higher, or for those with a BMI of 27 or higher who also have at least one weight-related condition such as high blood pressure, high cholesterol, or sleep apnea
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