Though allergies to cobalt are rarely dangerous, taking any form of B12 supplement, whether by injection, tablet, or topically applied gel, may result in an uncomfortable, itchy rash
Overall, the findings from these two recently completed cardiovascular outcomes trials suggest that the increases in HR associated with the short-acting GLP-1 RA, lixisenatide, or the long-acting GLP-1 RA, liraglutide, do not lead to an increased risk of major adverse cardiac events in patients with T2DM and high cardiovascular risk
Understanding these predispositions supports provider conversations about personalized dosing strategies that balance efficacy, safety, and long-term affordability
Though cross-trial comparisons are inherently flawed, Lilly has previously tied retatrutide to average reductions in A1C of 1.7%, 1.9% and 1.9% on the 4-mg, 9-mg and 12-mg doses, respectively, after 40 weeks of treatment and when accounting for all patients in its study