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In the gutkidney axis, barrier disruption may accelerate systemic toxin exposure and promote renal damage [356, 358], while in the gutheart axis, it may contribute to endothelial dysfunction and chronic vascular inflammation [359]

[18] While higher levels of homocysteine have been associated with numerous health complications, levels of homocysteine that are too low can also be problematic and have been associated with peripheral neuropathy (often felt as hand and arm tingling) and an impaired ability to make glutathione, an important antioxidant that reduces inflammation in the body

& Kril, J