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H 2 O 2 produced during the oxidative folding of endoplasmic reticulum proteins has been found to regulate the signal transduction process of nuclear factor E2-related factor 2 (Nrf2), which in turn regulates the expression of downstream glutathione peroxidase 8 (GPX8), which in turn can participate in ER calcium regulation through endoplasmic reticulum calcium ATPase (SERCA) (Granatiero et al., 2019) (Figure 7)
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As with anything nutrition-related, consult with a registered dietitian or your primary care physician before adding any new supplements to your regimen (or making any significant dietary changes, for that matter)
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