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GLP-1 agonist mechanism of action in cardiovascular tissues Once activated, GLP-1 receptors trigger multiple signaling pathways that collectively contribute to cardioprotection

It has been studied extensively in animal models for its ability to accelerate healing of tendons, ligaments, muscle, gut lining, and nerve tissue

There were two other dual agonists whose sequence has been reported so far, Tyr 1 has been used in MAR709 (designed by Finan et al in 2013, described by numerous other names: DA5-CH, DA-JC1, NNC0090-2746, RG7697, etc.) and His 1 has been used in CY-5 (Figure 3)

Serious adverse events were rare and not dose-dependent