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38,39 In the hippocampal tissue of type 2 diabetic mice, the expression of mitochondrial dynamin-related protein 1 (Drp1) increased, whereas inhibition of Drp1 restored neuronal function
Type 2 diabetes and the risk of Parkinsons disease
In the CREDENCE trial (The Evaluation of the Effects of Canagliflozin on Renal and Cardiovascular Outcomes in Participants with Diabetic Nephropathy), the relative risk of the primary outcome (doubling of serum creatinine, end-stage renal disease, or mortality attributable to a cardiovascular or renal cause) was 30% lower with canagliflozin versus placebo among patients with T2DM and albuminuric kidney disease well treated with renin-angiotensin system inhibitors
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