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Rather than targeting IGF-IR/InsR themselves, an alternative strategy would be inhibition of the master regulators of RTKs or downstream signaling hubs such as IRS1/2 [205,206,207,208]

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S9a), suggesting that Trim37 deficiency leads to the loss of PGCs prior to E12.5

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Dysregulation of the hypothalamicpituitaryadrenal axis increases central body fat accumulation in males affected by diabetes mellitus and late-onset hypogonadism

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