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Abbreviations ESLD: End-stage liver disease OLT: Orthotropic liver transplantation PHHs: Primary human hepatocytes ECM: Extracellular matrix MMP: Matrix metalloproteinase TIMP: Tissue inhibitor of metalloproteinase MSC: Mesenchymal stem cell MELD: Model for end-stage liver disease ALB: Albumin ALT: Alanine aminotransferase TBil: Total bilirubin UCMSC: Umbilical cord mesenchymal stem cell BMMSC: Bone marrow mesenchymal stem cell HSC: Hematopoietic stem cell GMP: Good manufacturing practice HGF: Hepatocyte growth factor PCNA: Proliferating cell nuclear antigen PAK2: P21-activated kinase-2 BMMNC: Bone marrow mononuclear cell IL: Interleukin IGFBP-2: Insulin-like growth factor binding protein-2 IL-1Ra: IL-1 receptor antagonist ADMSC: Adipose-derived mesenchymal stem cell LDMSC: Liver-derived mesenchymal stem cell MenSC: Menstrual blood-derived mesenchymal stem cell SSEA4: Stage-specific embryonic antigen 4 -SMA: Alpha smooth muscle actin TGF-1: Transforming growth factor-1 MCP-1: Monocyte chemoattractant protein-1 SHED: Stem cells from human exfoliated deciduous teeth TNF-: Tumor necrosis factor- G-CSF: Granulocyte-colony stimulating factor BMSC: Bone marrow stem cell VEGFR: Vascular endothelial growth factor receptor GSH: Glutathione TAC: Total antioxidant capacity GPx: Glutathione peroxidase CAT: Catalase SOD: Superoxide dismutase EPC: Endothelial progenitor cell vWF: Von Willebrand factor VEGF: Vascular endothelial growth factor IGF-1: Insulin-like factor-1 bFGF: Basic fibroblast growth factor EGF: Epidermal growth factor LPC: Liver progenitor cell HLC: Hepatocyte-like cell FGF2: Fibroblast growth factor 2 FGF4: Fibroblast growth factor 4 BMP4: Bone morphogenetic protein 4 OSM: Oncostatin M AFP: -Fetoprotein A1AT: Alpha-1-antitrypsin HNF4: Hepatocyte nuclear factor 4 ESC: Embryonic stem cell iPSC: Induced pluripotent stem cell CXCL12: Chemokine ligand 12 SDF-1: Stromal cell-derived factor-1 LSEC: Liver sinusoidal endothelial cell CXCR: Chemokine receptor VACM-1: Vascular cell adhesion molecule-1 FAK: Focal adhesion kinase ILK: Integrin-linked kinase IGF1R: Insulin-like factor 1 receptor CM: Conditioned medium Ang-1: Angiotensin-1 Flt1: Fms-like tyrosine kinase 1 Flk1: Fetal-like kinase 1 HB-EGF: Heparin binding epidermal growth factor-like growth factor CTGF: Connective tissue growth factor PGE2: Prostaglandin E2 TSG-6: TNF simulated gene/protein 6 IDO: Indolamine 2,3-dioxygenase DC1: Type 1 dendritic cell DC2: Type 2 dendritic cell Th: T-helper Th1: T-helper 1 Th17: T-helper 17 Gal-9: Galectin-9 Treg: Regulatory T cell HLA-G5: Human leukocyte antigen-5 IL-2R: IL-2 receptor IFN-: Interferon- iNOS: Inducible nitric oxide synthase NOXs: NADPH oxidases ROS: Reactive oxygen species RNS: Reactive nitrogen species MDA: Malondialdehyde HO-1: Hemeoxygenase-1 COX: Cytochrome-c oxidase SDH: Succinate dehydrogenase PRL-1: Phosphatase of regenerating liver-1 ER: Endoplasmic reticulum EGFR: Epidermal growth factor receptor BMMSC-Exos: BMMSC-derived exosomes EMT: Epithelial-mesenchymal transition MFGE8: Milk fat globule-EGF factor 8 TGFBR1: TGF- type I receptor PPAR: Peroxisome proliferator-activated receptor AMSC: Amnion-derived mesenchymal stem cell Col1a1: Type I collagen Col3a1: Type III collagen sFRP2: Secreted Frizzled-related protein 2 EVs: Extracellular vesicles VSG-G: Variant surface glycoprotein-G References Asrani SK, Devarbhavi H, Eaton J, Kamath PS

USA 84 , 53115315 (1987)

For persistent lumps or bumps, gentle massage may help disperse the injected solution and speed resolution

8 weeks 1 vial Covers early titration (40-80 unit draws)