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Because GLP-1 therapy helps men lose weight and improve their overall health, experts say the connection between GLP-1 medications and improved male fertility makes sense from a medical standpoint
Alternative approaches to consider before combining medications Before taking the step of adding phentermine to tirzepatide, consider whether any of these evidence-based alternatives might address your plateau or treatment goals without the added risk of combination therapy
The first induction study FIGARO UC 301 (NCT03259334) randomized 380 participants in a 2:2:1 ratio to receive ontamalimab 25mg, 75mg, or placebo subcutaneously at weeks 0, 4, and 8, with the primary endpoint of clinical remission at week 12 showing the 75mg dose achieved statistically significant results at 29.8% versus 15.8% placebo while the 25mg dose did not reach significance at 18.5%, along with superior secondary endpoints including endoscopic response, clinical response, and mucosal healing all favoring the 75mg dose (51)
Fatigue is a documented side effect in FDA prescribing information, reported in 11.4% of Wegovy users and 7.2-10.8% of Zepbound users during clinical trials
