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The reaction was terminated as described, and the poly (ADP-ribosyl) ation was visualized by immunoblotting with an anti-PAR1 antibody (Shrestha et al., 2016)

751 participants across 32 sites in the United States and Puerto Rico 72-week treatment duration 1:1 randomization to Tirzepatide or Semaglutide Maximum tolerated dose used for both medications Primary endpoint: percent change in body weight at week 72 Participants received either the maximum tolerated dose of Tirzepatide (10mg or 15mg) or the maximum tolerated dose of Semaglutide (1.7mg or 2.4mg)

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