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Despite their overall safety profile, older adults taking GLP-1s who have frailty or a history of heart attack or stroke may need additional clinical support to ensure that they are meeting their nutritional needs and getting sufficient physical activity to mitigate reductions in muscle mass and function
You can typically expect to begin losing weight within the first 60 days
B12 absorption also gets harder with age, independent of any medication
Peptides discussed below are research compounds
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![Mechanism of action of GLP-1 [25]](https://www.researchgate.net/profile/Asfandyar-Sheikh/publication/256289222/figure/fig1/AS:614177232142337@1523442671231/Mechanism-of-action-of-GLP-1-25.png)
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