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But the mechanistic rationale is strong, the safety profile appears favorable, and the early observational data aligns with what the biochemistry predicts
Population Doubling Level Calculation To calculate the PDL, a formula was used as follows: n = 3.32 (log UCY log I ) + X , where n is the final PDL at the end of a given subculture, UCY is the cell yield at that point, I is the cell number used as inoculum to begin that subculture, and X is the PDL of the inoculum used to initiate the subculture being quantitated (Pham et al., 2020)
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For this reason, NAD + and SAM observations are best treated first as pathway-engagement data, and only secondarily as safety-relevant information when paired with appropriate monitoring endpoints
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