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Subsequently, emphasis will be focused on the GSH-responsive and -exhausting metal nanomedicines for sensitized therapies, such as chemotherapy, PDT, sonodynamic therapy (SDT), CDT, ferroptotic therapy, and radiotherapy
It is essential for the production of red blood cells, the synthesis of DNA, and the metabolism of energy in addition to its role in nerve function
The transcription factor p53 also plays a dual role in melanocyte defense by upregulating tyrosinase, a key enzyme in melanogenesis, and enhancing the antioxidant response via the Nrf2 pathway 17 , but also it can stop the melanocyte cell cycle, even leading to apoptosis 79
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