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gradual titration reduces incidence [1] [5]
Its used to treat deficiencies in both vitamins at once
Protein Synthesis: B12 plays a role in protein metabolism, which is vital for muscle repair and growth
The biphasic response suggests possible mechanisms: lower doses (nanogram range) might work through growth factor upregulation and signaling cascade amplification, while higher doses (microgram range) might involve direct receptor activation or substrate provision for cellular repair
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