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Diabetologia (2016) 59(2):26674
Scientific References Retatrutide Phase 2 obesity trial GLP-1/GIP/glucagon triple agonist (Jastreboff et al., Eli Lilly)
Apart from these modes of action, riboflavin has also been shown to activate specific neuroactive molecules such as vitamin B 6 (which confers neuroprotection based on a role in serotonin production) 73 , homocysteine (which has a double-edged neurological role) 74 and kynurenine involved in glutamate excitotoxicity (i.e., excess of glutamate in neural synapse, resulting in death of neural cells) 75
IcoSema (icodec + semaglutide) may represent an exciting future direction by combining weekly basal insulin with GLP-1 therapy
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