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Proper technique involves cleaning the injection site with alcohol, pinching the skin to create a fold, inserting the needle at a 45-90 degree angle, injecting slowly, and rotating injection sites to prevent irritation

Research published by Brines & Cerami (2012) in Molecular Medicine demonstrated that ARA-290 downregulates pro-inflammatory cytokines including TNF-, IL-6, and IL-1 while upregulating anti-inflammatory mediators

Small pilot studies and open-label trials have evaluated intra-articular AOD-9604 in patients with knee OA, typically injecting 5-10 mg monthly for 3-6 months

Yao WC, Chen HJ, Leong KH, et al