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[3] Glucocorticoids (like prednisolone) are among the most common causes of secondary osteoporosis, and they work partly by suppressing GH/IGF-1 signaling

doi: 10.1073/pnas.2212476120 125 Azarcoya-BarreraJWollinBVeida-SilvaHMakarowskiAGorukSFieldCJet al

By attenuating inflammation and oxidative stress, curcumin improves insulin receptor signaling and enhances insulin sensitivitymechanisms that are particularly relevant given the shared inflammatory and insulin-resistant states underlying diabetes and depression (Sarmiento-Ortega et al., 2025)

[67] [68] Supplementing the diet with folic acid and vitamin B 12 lowers plasma homocysteine