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Their functional plasticity, shifting between inflammatory, repair, or anti-inflammatory states, depends on metabolic adaptation and lipid remodeling, including choline uptake and phospholipid reorganization ( 2.1.1 Macrophages and dendritic cells Macrophage functions, such as cytokine and chemokine secretion, phagocytosis, and organelle biogenesis, are intricately linked to membrane phospholipid composition, curvature, and charge ( Figure 3 )
Both semaglutide and tirzepatide are designed to be used long-term, meaning patients may regain weight if the treatment is stopped
It is also prescribed for long-term weight management in adults and adolescents aged 12 years and older with obesity, and in adults with overweight who have a weight-related health condition
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