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The most commonly reported adverse effects in these trials were gastrointestinal in nature including nausea, vomiting, diarrhoea, and constipation consistent with the GLP-1 receptor agonist class effect

They are available in the United States through compounding pharmacies under 503A and 503B frameworks meaning they can be legally prepared and prescribed by licensed physicians for individual patients on a compounded basis

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Comparative gastrointestinal adverse effects of GLP-1 receptor agonists and multi-target analogs in type 2 diabetes: A Bayesian network meta-analysis