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Leptin-induced regulation of Bdnf mRNA expression is mediated by stimulation of an AKT/p300 HAT/H3 modification cascade The binding of leptin to LepRb activates three major signaling pathways, i.e., JAK2/STAT3, PI3K/AKT, and ERK pathways [68] (Fig

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Clinical Trial Registration: identifier: NCT01366859

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