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Neurological & Psychiatric Effects Reduces Neuroinflammation & Neurodegeneration: Decreases inflammation and degeneration in the brain
(48) did not support the existence of this proximal-distal incretin loop in humans as intravenous injection of GIP into humans did not enhance GLP-1 secretion, pointing to the fact that the animal models may differ from humans in essential physiology
Animal Model:Neonatal Sprague-Dawley rats (male, 18-22g, postnatal day 7), hypoxic-ischemic brain damage (HIBD) model [2] Dosage:100 mg/kg Administration:Intraperitoneal injection, once daily, for 14 consecutive days starting 24 hours after HIBD induction Result:Brain injury: Reduced infarct volume by 40% compared to the HIBD control group as measured by triphenyltetrazolium chloride (TTC) staining
Cork said any reduction in cost was to be welcomed, not least because at present GLP-1 analogues can only be prescribed for use for two years on the NHS for eligible patients
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