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[52], fatty acid oxidation might increase mitochondrial acetyl-CoA levels through -oxidation and subsequently inactivate pyruvate dehydrogenase, which in turn, would increase intracellular citrate levels and inhibit phosphofructokinase (a key glycolytic enzyme), and lead to the accumulation of intramyocellular glucose-6-phosphate, which inhibits hexokinase activity and causes the accumulation of intramyocellular glucose and reduced glucose uptake (Fig

Sources New England Journal of Medicine: Once-Weekly Semaglutide in Adults with Overweight or Obesity New England Journal of Medicine: Tirzepatide Once Weekly for the Treatment of Obesity Diabetes, Obesity and Metabolism: A Journal of Pharmacology and Therapeutics: Semaglutide for the treatment of overweight and obesity: A review JAMA Network: Weight Loss Outcomes Associated With Semaglutide Treatment for Patients With Overweight or Obesity American Diabetes Association: Standards of Medical Care in Diabetes, 2025 Harvard Health Publishing: GLP-1 diabetes and weight-loss drug side effects: Ozempic face and more University of Illinois Chicago: What efficacy data are available on the use of tirzepatide for obesity

Effects of once-weekly subcutaneous retatrutide on weight and metabolic markers: a systematic review and meta-analysis

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