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Possible pathways that could alter anxiety or mood include: Effects on neurotransmitters such as dopamine and serotonin that shape motivation and pleasure Changes to gut-brain signaling that alter satiety and reward Shifts in systemic inflammation that can modulate mood circuits Improved glycemic control that reduces glucose swings known to trigger irritability or nervousness Each pathway offers a plausible biological link, though none yet proves a direct, consistent anxiolytic or depressogenic drug effect

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Mast cells are important for mediating inflammatory responses, which are deemed crucial during the initial phases of wound healing