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In the SURMOUNT-1 trial, participants without diabetes lost an average of 15-20% of their body weight over 72 weeks at the 10 mg and 15 mg doses, though results may vary in different populations

Encouraging results from phase IIa and IIb studies have paved the way for phase III clinical trials 6

The brain's ability to utilize glucose becomes measurably impaired, creating an energetic deficit at the neuronal level

These receptors are widely distributed throughout the central nervous system and peripheral tissues, mediating diverse physiological functions including pigmentation, energy homeostasis, sexual function, inflammation, and cardiovascular regulation