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Use comfort-first textures and add soothing/barrier supports Provide a start slow plan for sensitive users Avoid asking consumers to stack too many strong actives at once 5
Leggatt, R
Topical is sufficient and has the most clinical evidence
ALOX15 is essential for ferroptosis induced by compounds (e.g., erastin or RSL3), as it forms a complex with PE binding protein 1 (PEBP1), specifically recognizing stearoyl-arachidonoyl-phosphatidylethanolamines and generating lipid peroxides [103]
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