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Why this matters: Forcing solvent directly onto the peptide cake at high speed can cause localized denaturation or foaming, which can reduce bioactivity

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Known history or presence of severe acute or chronic liver disease (compensated or decompensated), known cholelithiasis or cholecystitis or bile duct disease, acute or chronic pancreatitis (or medication associated with severe pancreatitis, such as valproate) or severe gastrointestinal dysmotility syndrome, including functional disorders such as severe irritable bowel syndrome