1 ml tirzepatide 10mg (10mg/mL + Methylcobalamin 500 mcg/mL) (1mL Vial) hormone GLP GLP-1/GIP Tirzepatide Rx | FancyMeds

This flexibility is a hallmark of metabolic health and is often impaired in individuals with obesity or insulin resistance

NICE guidance on tirzepatide for type 2 diabetes (TA924) acknowledges the theoretical thyroid cancer risk based on animal data but notes the limited evidence for increased risk in humans

It is also worth noting that rapid weight loss associated with GLP-1 receptor agonist therapy is linked to an increased risk of gallstone formation and gallbladder disease (cholecystitis), a class effect recognised in the SmPCs for semaglutide and tirzepatide

In this scenario, greater degradation of GLP-1 (and the other incretin, GIP), with a consequent impairment of the incretin effect would contribute to worsening of glycaemic control