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Tirzepatide, a dual GIP/GLP-1 receptor co-agonist for the treatment of type 2 diabetes

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While the specific details of the ECD interface of Cagri-AMY 3 R could not be determined due to the low-resolution maps, these findings are indicative of substantial loss of RAMP3/CTR ECD interface interactions and considerable dynamic motions within the RAMP3 and CTR ECD protomers (Fig