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It does not seem to be entirely driven by tissue damage, as highlighted by the discordance between pain and structural changes in OA joints 38
Further increments are made in stepwise fashion as per the prescribing information, with many adults eventually reaching a dose of 2.4 mg once weekly for long-term management of obesity or excess weight in conjunction with diet and exercise
And the results fell below the 25% target Novo itself had dangled before investors as the trials likely outcome
We cover what to expect and how to manage it in our semaglutide side effects guide
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