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Retatrutide is currently in clinical trials and not yet approved by Health Canada or the FDA for general use

Retatrutide is not available as a licensed treatment through the NHS, and any use outside of an approved clinical trial would be considered unlicensed

As well as increasing insulin secretion, GLP-1 also increases the feeling of fullness during and between meals by acting on appetite centres in the brain and by slowing gastric emptying - which is a fancy way of saying it slows down the process by which the stomach sends its partly digested contents down into the intestine

Published meta-analyses and systematic reviews indicate that both oral and injectable GLP-1 RAs delay gastric emptying, but the magnitude of this effect is similar across formulations when matched for agent and dosing schedule