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But this was mostly because they lost so much weight in the first place, according to the British researchers who conducted the largest and most up-to-date review of the subject

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Systemic inhibition of DPP-4 activity reduced lipid excursion and increased active GLP-1 in HFD-fed Dpp4 EC+/+ mice, but not in Dpp4 EC/ mice (Figure 7, AD)