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You might think that would at least coincide with a superior safety profile, but that same study saw a greater rate of trial discontinuation due to adverse effects in the liraglutide group than in the semaglutide group.7 It also requires daily dosing, which is less convenient than the weekly administration of semaglutide and tirzepatide
Nguyen A et al
That means retatrutide may produce a wider physiological pattern in laboratory models, but it can also complicate causality
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