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In mouse and rat models of choline and methionine-deficient diet-induced metabolic dysfunction-associated steatotic liver disease (MASLD), females are reported to be more protected than their male counterparts 88

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5,6 These precedents illustrate a broader principle: cell death can unfold as a tissue-level process in which the demise of one cell actively shapes and sometimes determines the fate of its neighbors

This selective deployment reflects an evolutionary refined defense strategy that balances metabolic cost with protective efficacy while enabling adaptation to diverse biotic challenges (Mierziak et al., 2014