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Thus, the NLRP3 inflammasome serves as a key mechanistic link between the initial toxic insult and the ensuing inflammatory response in APAP hepatotoxicity

These effects typically diminish as the body adapts

A simplified protocol for differentiation of electrophysiologically mature neuronal networks from human induced pluripotent stem cells

Finally, the results of the above studies have provided strong evidence that single or multiple exposures to general anesthesia may not lead to reduced IQ scores in later childhood, while receiving multiple exposures to anesthesia might increase the risk of neurodevelopmental impairment and long-term cognitive dysfunction (Figure 1)