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The starting dose is 3 mg taken for the first month, which is then increased to 7 mg in the second month, and can be further increased to the maximum dose of 14 mg thereafter based on glycemic response and tolerability

Two key enzymes, acyl-CoA synthetase long-chain family member 4 (ACSL4) and lysophosphatidylcholine acyltransferase 3 (LPCAT3), are involved in the biosynthesis and remodeling of PEs, activation of PUFAs, and insertion of PUFAs into membrane PLs (Doll et al., 2017)

The BBSome comprises 8 core proteins (BBS1, BBS2, BBS4, BBS5, BBS7, BBS8, BBS9, and BBS18) that operate collectively to regulate the transport of receptor molecules within cilia

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