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Lyketsos et al., 2002
IGF-1 LR3s markedly reduced IGFBP affinity allows researchers to study sustained, IGFBP-independent IGF-1R signalling in a way that is not practically achievable with native IGF-1
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Before combining medications, discuss optimizing your current therapy by ensuring adequate dosing and treatment duration, exploring FDA-approved alternatives like tirzepatide or phentermine-topiramate ER, intensifying lifestyle interventions with behavioral therapy, or considering metabolic surgery if you meet clinical criteria
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