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Ideal Candidates Include: People with Metabolic Dysfunction: Type 2 diabetes or pre-diabetes Insulin resistance Metabolic syndrome Obesity or trouble losing weight High triglycerides or cholesterol Fatty liver disease (NAFLD) PCOS (polycystic ovary syndrome) Those Experiencing Low Energy and Fatigue: Chronic fatigue syndrome Mitochondrial dysfunction Low energy despite adequate sleep Poor exercise tolerance or endurance Difficulty recovering from physical activity Athletes and Active Individuals: Wanting to improve endurance capacity Seeking better recovery between training sessions Looking to optimize body composition Aiming to enhance metabolic efficiency Preparing for competitions or events Aging Adults Focused on Longevity: Age 40+ seeking to prevent metabolic decline Interested in health span extension Wanting to maintain muscle mass and function Concerned about age-related disease prevention Seeking cognitive protection as they age Anyone Struggling With: Weight loss resistance despite diet and exercise Visceral (belly) fat accumulation Poor metabolic flexibility Brain fog and cognitive issues Declining physical performance with age Combining MOTS-C With Other Therapies MOTS-C works synergistically with other metabolic optimization strategies, often producing enhanced results when properly stacked

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For Fried criteria, the study used the cutoff points of hand grip and gait speed from the original study published by Fried et al 27 conducted on a Western population rather than Asian

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