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This evidential gapwhere symptom improvement is confirmed but reproductive benefit remains unknownclearly defines the critical breakthrough direction for future translational research: there is an urgent need to establish a multidimensional evaluation system integrating objective microenvironmental markers (e.g., seminal plasma inflammatory cytokines/oxidative stress markers)semen quality/DFIreproductive outcomes. This is essential to definitively validate the clinical value of microenvironment remodeling interventions in preserving male fertility

S8244) or its vehicle (water) was added 20 min before the assay

Vendeville, A

Preliminary Human Evidence Evidence is limited to small, early, uncontrolled, or incomplete human studies