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Symptoms are most likely to appear during dose increases or near the target dose and often improve as the body adjusts over time
doi: 10.1016/j.aquaculture.2020.735944 152 LiuYYuMCuiJDuYTengXZhangZ
Cases of localized skin and soft tissue necrosis occurring as sequelae of penile hematoma, some requiring surgical intervention, have been reported post-marketing Hypersensitivity Reactions, Including Anaphylaxis: In the double-blind, placebo-controlled portions of the clinical trials in Peyronies disease, a greater proportion of XIAFLEX-treated patients (4%) compared to placebo-treated patients (1%) had localized pruritus after up to 4 treatment cycles (involving up to 8 XIAFLEX injection procedures)
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