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Some patients on GLP-1 therapy see regain when stopped if dietary habits weren't changed this is a habits issue, not a compound dependency
Research dose/evidence: Some cosmetic studies show Acmella extract (the source of spilanthol) improves wrinkle appearance, but there are fewer large clinical trials than for retinoids or peptides (there never are with botanical extracts)
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Overall, available evidence supports NACs safety and potential early advantage, but long-term benefit has not been consistently demonstrated
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