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Michael Somenek, a clinical investigator in the groundbreaking Galderma study, notes that as medication-driven weight loss becomes more prolific around the world, so do the associated impacts of facial volume loss and other unwanted cosmetic effects like shadowing and hollowness. The Science Behind Facial Changes with GLP-1 Medications The 2025 Galderma clinical trial confirms what weve been observing in our practice at Aestha Clinic
Interestingly, exendin-4 (939), an antagonist of GLP-1R (Avexitide, Phase III), has been shown earlier to bind to the ECD of GLP-1R with an orientation different than that of GLP-1
N Engl J Med 2016;375:1834-44.ArticlePubMed 90
Some of these serums contain hydrating elements that keep the skin moisturized and eliminate the problem of dryness
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