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4.3 Evaluation of current clinical evidence Based on current research, three consistent clinical characteristics can be identified: (1) systemic iron metabolism indicators suggest that iron homeostatic imbalance (characterized by iron overload or utilization disorders) is positively correlated with the risk of DKD (Wu et al., 2020

This antioxidant activity preserves mitochondrial function in metabolically demanding retinal cells, maintaining the high energy requirements for phototransduction processes

The safety profile is encouraging

Ethical approval was obtained from the IRB committees at Faculty of Medicine, University of Helsinki, Helsinki, Finland, and at Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA