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In addition, DMF mediates a time-course-dependent effect to induce DNA hypomethylation on reactive oxygen species (ROS) regulatory genes such as NRF2, CES1-3, GSTA1-5, NOX1-5, NQO1, and TXNRD1 30
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The three liver fluke species have complex life cycles with definite hosts (i.e., humans and some animal reservoir hosts) and two kinds of intermediate hosts (i.e., freshwater snails and freshwater fish), characterized by an alternation of sexual and asexual reproduction in the different hosts (1113) (Fig
A meta-analysis has indeed highlighted that only about 5060% of patients with diabetes adhere to antidiabetic therapy [69], with a significant impact on quality of life and life expectancy
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