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Certain pain medicationsparticularly opioidscan increase pain sensitivity over time through a process known as opioid-induced hyperalgesia

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6 Mitochondria-targeted therapeutic strategies for ROS regulation 6.1 Antioxidant compounds Antioxidants play a pivotal role in combating skeletal muscle atrophy by neutralizing excessive reactive oxygen species (ROS) or enhancing endogenous defense systems

However, protein misfolding within the ER triggers ER stress, which induces the UPR, a distinct signaling pathway that aims to relieve this stress (Matus et al., 2013