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The mouse model used for these experiments is a general knockout and we can therefore discount the possibility that GLP-1 exerts its inhibitory action by paracrine effects secondary to activation of GLP-1Rs in delta and beta cells, suggesting that GLP-1s glucagonostatic effect involves a receptor distinct from GLP-1R
Its also important to know that tirzepatide also reduces how much of an oral birth control pill the body absorbs, which may cause some women to become pregnant unexpectedly
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J., Zhang, V., Gratzl, S., et al
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