semaglutide withdrawal reddit What we still don't know about Wegovy's effect on strokes and heart attacks The weight-loss drug Wegovy may

A 28% reduction in body weight is not more weight loss in the sense that a 17% reduction is more than a 12% reduction

Xiao L, Zhang H, Wang Y, Li J, Yang G, Wang L, et al

Among 169,649 patients with MASLD, GLP-1 receptor agonist initiation was linked to significantly lower probability of incident cirrhosis [adjusted hazard ratio (aHR): 0.86, 95%CI: 0.80-0.93], hepatic decompensation (aHR: 0.77, 95%CI: 0.65-0.90), and hepatocellular carcinoma (HCC) (aHR: 0.79, 95%CI: 0.68-0.92) over a median follow-up of 3.5 years compared to non-users

Phase 3 trials are the large-scale, randomised controlled studies required to establish efficacy and safety across diverse patient populations before a regulatory submission can be made