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Most patients notice changes in appetite and reduced cravings within the first four weeks of treatment
Lipotropics are substances that help stimulate the breakdown of lipids in the body and thereby reduce the accumulation of excess fat in the liver
However, patients who have previously failed adrenergic-based weight-loss strategies (e.g., phentermine non-responders) should raise the clinical suspicion that ADRB3 variants are limiting downstream signal transduction
What the drug-alone data does show is that mice lost fat with no change in food intake, so the effect is not simply appetite suppression
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